Animal. graphic Haemophilia. Manage_data ../concept/data_management. Haemophilia. Data_management ../concept/data_management. GO_gene_ontology. Discussion ../content/gene_ontology. GO_gene_ontology. Summary ../content/gene_ontology_go. Haemophilia. CJD_prions ../genetics/prion.htm Haemophilia. Employment ../medicine/agenda_for_change. Haemophilia. association ../medicine/health_care. Haemophilia. is_type_of ../medicine/medicine. Haemophilia. Type_B 20% of cases, (lacking in factor IX [9]) Haemophilia. Type_A 80% of cases, (lacking in factor VIII [8]) Haemophilia. Data_collection Clinical_coding Haemophilia. Risk Risk_assessment Haemophilia. Society Haemophilia Society Haemophilia. APTT Activated Partial Thromboplastin Time Haemophilia. CJD, mad cow disease Patient_letter (PDF) Haemophilia. Data_collection_Canada Canada Haemophilia. Haemotology Haemotology at Southampton Haemophilia. Haemophilia_treatment Southampton Bookings Haemophilia. Southampton_patient_opinions Patient_feedback Haemophilia. Aquired_haemophilia Myocardial_infarction Haemophilia. Southampton Southampton University Hospitals Haemophilia. ../concept/statistics. Statistics_about_Haemophilia Telomere. graphic Virus. description Although they reproduce, they can only do so only by entering a host cell and making use of its machinery for replication. Viruses are bits of genetic material, apparentlyderived from their hosts. Thus, as Margulis and Schwartz (1988) put it, the polio and flu viruses are probably more closely related to people, and the tobacco mosaic virus (TMV) to tobacco, than polio and TMV are to each other Living_organism. has_type Animal. Bacterium. is_type_of Animal. Bacterium. graphic Biological_pathogen. has_type Bacterium. Fungus. is_type_of Biological_pathogen. Bacterium. is_type_of Biological_pathogen. Protozoan. is_type_of Biological_pathogen. Virus. is_type_of Biological_pathogen. Prion. is_type_of Biological_pathogen. Haemophilia. Symptons Bleeding, Bruising easily, Clotting difficulty Exon. is_part_of Chromosome. Intron. is_part_of Chromosome. Genome. has_part Chromosome. Chromosome. has_part Ciston (encodes a protein) DNA. Stands for Deoxyribo Nucleic Acid Nucleotide. is_part_of DNA. Genome. has_type Eukaryotic Chromosome. has_part Exon. DNA. has_part Exon. Biological_pathogen. has_type Fungus. Fungus. graphic Chromosome. has_part Gene. Genetics. graphic Genetics. has_type Genome. Chromosome. is_part_of Genome. Organisation. has_instance GO_gene_ontology. Haemophilia. Royal_family Allopatric. How species originate http://en.wikipedia.org/wiki/Allopatric_speciation Sympatric. Speciation http://evolution.berkeley.edu/evosite/evo101/VC1eSympatric.shtml Telomere. Atlas http://genes.uchicago.edu/telomere/telomere.html Gene. Drawing http://intron.bic.nus.edu.sg/exint/descrip.html Haemophilia. Fragile_X_chromosome http://jmg.bmj.com/cgi/content/abstract/31/12/950 Chromosome. Fragile X chromosome http://jmg.bmj.com/cgi/content/abstract/31/12/950 Haemophilia. Haemophilia_types_source http://kidshealth.org/teen/diseases_conditions/blood/hemophilia.html DNA. History http://library.thinkquest.org/20830/Textbook/HistoryofDNAResearch.htm Nucleotide. Explained http://life.fudan.edu.cn/inforservice/dictionary/Glossary/nucleoti.htm Protozoan. Sporozoan http://orion1.paisley.ac.uk/courses/Tatner/biomedia/units/prot6.htm Intron. Discussion http://post.queensu.ca/~forsdyke/introns.htm#Introns%20Introduction Nucleotide. Metabolism http://themedicalbiochemistrypage.org/ Haemophilia. UKCDO, UK Haemophilia Centre Doctors Organisation http://ukhcdo.org/ Haemophilia. Centres http://ukhcdo.org/HaemophiliaCentres/areacontactslist.htm Haemophilia. VisWiki http://viswiki.com/en/Haemophilia Transcription. Diagram http://www.accessexcellence.org/AB/GG/central.html Gene. Regulation http://www.accessexcellence.org/AB/GG/combi_Control.html DNA. Diagram http://www.accessexcellence.org/AB/GG/dna_molecule.html Exon. Diagram http://www.accessexcellence.org/AB/GG/exon.html Meiosis. Explained http://www.accessexcellence.org/AB/GG/meiosis.html Meiosis. graphic, linked Nucleotide. Diagram http://www.accessexcellence.org/AB/GG/nucleotide2.html RNA. Diagram http://www.accessexcellence.org/AB/GG/rna.html Nucleosome. description http://www.accessexcellence.org/RC/VL/GG/nucleosome.html Telomere. Ageing Theory http://www.aeiveos.com/agethry/telomere/ Nucleosome. Incorporation into Chromatin http://www.albany.edu/~achm110/nucleosome.html Nucleosome. description http://www.average.org/~pruss/nucleosome.html Fungus. Traps http://www.biological-research.com/philip-jacobs%20BRIC/fangorg.htm Mitosis. Animation http://www.cellsalive.com/mitosis.htm Organisation. EMBL_Bank http://www.ebi.ac.uk/embl/Access/index.html Exon. definition http://www.genome.gov/glossary.cfm?key=exon Rna_polymerase. Diagram http://www.genome.jp/kegg/pathway/map/map03020.html Haemophilia. Definition http://www.healthline.com/galecontent/hemophilia-1 GO_gene_ontology. Web_interface, genes http://www.informatics.jax.org/searches/GO.cgi?id=GO:0030101 Gene. Gene terms http://www.informatics.jax.org/searches/GO.cgi?id=GO:0030101 GO_gene_ontology. Web_interface http://www.informatics.jax.org/searches/GO_form.shtml Uni_gene. definition http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=unigene Genome. Human. http://www.ncbi.nlm.nih.gov/mapview/map_search.cgi?chr=hum_chr.inf&query Intron. Purpose http://www.newton.dep.anl.gov/askasci/bio99/bio99375.htm Haemophilia. What_causes_haemophilia? http://www.nhlbi.nih.gov/health/dci/Diseases/hemophilia/hemophilia_causes.html Haemophilia. Safe_sedation http://www.rcr.ac.uk/publications.aspx?PageID=310&PublicationID=186 Virus. Image http://www.rkm.com.au/imagelibrary/index.html Organisation. Sanger_institute. http://www.sanger.ac.uk/ Sanger_institute. Cancer Genome Project http://www.sanger.ac.uk/genetics/CGP/ Genome. description http://www.uq.edu.au/vdu/BasicsCell.htm Chromosome. description http://www.uq.edu.au/vdu/DNAGenes.htm Bacterium. Predates Human. Virus. Predates Human. Prion. Predates Human. Human. graphic Haemophilia. ICD_10_codes III D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Chromosome. has_part Intron. DNA. has_part Intron. Biological_pathogen. has_type Invisible to naked eye Chromosome. association Lariat Allopatric. description Live in different locations Sympatric. description Live in same location Animal. is_type_of Living_organism. Biological_pathogen. is_type_of Living_organism. Fungus. is_type_of Living_organism. Virus. is_type_of Living_organism. Prion. is_type_of Living_organism. Protozoan. graphic Prion. Definition Natural proteins that have changed in a harmful way, are hard to remove from the food chain and are infectious: Fungus. Predates Nematode. Nucleosome. graphic Gene. has_part Nucleotide. DNA. has_part Nucleotide. RNA. has_part Nucleotide. Haemophilia. Haemophilia_severe Only produce 1% of the clotting factor Haemophilia. Haemophilia_moderate Only produce 2% to 5% of the clotting factor Genetics. has_type Organisation. GO_gene_ontology. is_instance_of Organisation. Sanger_institute. is_type_of Organisation. Bacterium. Predation Parasitism. Virus. Predation Parasitism. Prion. Predation Parasitism. Biological_pathogen. graphic Haemophilia. Procedure Peripheral blood stem cell harvesting Haemophilia. Procedure Plasma exchange Parasitism. definition Predation without killing host Biological_pathogen. has_type Prion. Prion. graphic Prion. description Prions are pathogenic variants of proteins that are naturally produced in nerve cells and certain other cells. The normal healthy prions are referred to as PrPc 0roteinaceous infectious particle and so should properly only be applied to the pathogenic variants. RNA that codes for PrPc is produced in the nucleus and exits via the nuclear pore. The RNA then passes along ribosomes attached to the rER. PrPc is formed in the rER and then progresses up through the Golgi. At the upper face of the Golgi, vesicles containing PrPc bud off and travel to the cell surface. Here, they fuse with the cell membrane and so discharge their cargo at PrPc. By this means, the cellular proteins come to sit on the exterior of the cell. PrPc encounter rogue (purple) prions. These are termed PrPsc (sc stands for scrapie, the prion disease of sheep). The rogue prions seem to force the normal proteins to change shape. Both types of protein, the PrPc and their corresponding prions, are the same chemical - just different shapes. It is this shape-flipping which is equivalent to the transmission of infection. Such a conformational shift or flip could happen at the cell surface or in caveolae (one is shown as a small invagination in the cell membrane). Residual PrPc might continue to be flipped by contact with the rogue confomations for some time in these vesicles. Prions polymerise, finally appearing as purple fibrils in the picture at P. PrPsc is resistant to degradation by the enzymes contained in the lysosomes that are seen floating nearby. Consequently, PrPsc accumulates in the cell. PrPsc vesicles may also travel to the Golgi and intercept PrPc that is being processed there. In this way, PrPc particles could be switched to the rogue form before they reach the surface of the cell. By such mechanisms, PrPc might be switched to PrPsc at various points in and on the cell. It must be emphasised that prion biology is not fully understood and much remains speculative Haemophilia. Haemophilia_mild Produce 6% to 50%of the clotting factor Genome. has_type Prokaryotic Genetics. has_type Proteome Biological_pathogen. has_type Protozoan. Haemophilia. Procedure Red cell exchange RNA. Stands for Ribonucleic Acid Nucleotide. is_part_of RNA. RNA. has_type Rna_polymerase. Chromosome. association Snurp Chromosome. has_part Telomere. Telomere. definition The end of a chromosome. This specialized structure is involved in the replication and stability of linear DNA molecules Haemophilia. Procedure Therapeutic leucapheresis Haemophilia. Procedure Therapeutic platelet apheresis DNA. association Transcription. Gene. Tool Uni_gene. Biological_pathogen. has_type Virus. Virus. graphic 153 total tuples     Vr.154, Jan 2009     Readme