Allopatric. description Live in different locations Allopatric. How species originate http://en.wikipedia.org/wiki/Allopatric_speciation Animal. graphic Animal. is_type_of Living_organism. Bacterium. graphic Bacterium. is_type_of Animal. Bacterium. is_type_of Biological_pathogen. Bacterium. Predates Human. Bacterium. Predation Parasitism. Biological_pathogen. graphic Biological_pathogen. has_type Bacterium. Biological_pathogen. has_type Fungus. Biological_pathogen. has_type Invisible to naked eye Biological_pathogen. has_type Prion. Biological_pathogen. has_type Protozoan. Biological_pathogen. has_type Virus. Biological_pathogen. is_type_of Living_organism. Chromosome. association Lariat Chromosome. association Snurp Chromosome. description http://www.uq.edu.au/vdu/DNAGenes.htm Chromosome. Fragile X chromosome http://jmg.bmj.com/cgi/content/abstract/31/12/950 Chromosome. has_part Ciston (encodes a protein) Chromosome. has_part Exon. Chromosome. has_part Gene. Chromosome. has_part Intron. Chromosome. has_part Telomere. Chromosome. is_part_of Genome. DNA. association Transcription. DNA. Diagram http://www.accessexcellence.org/AB/GG/dna_molecule.html DNA. has_part Exon. DNA. has_part Intron. DNA. has_part Nucleotide. DNA. History http://library.thinkquest.org/20830/Textbook/HistoryofDNAResearch.htm DNA. Stands for Deoxyribo Nucleic Acid Exon. definition http://www.genome.gov/glossary.cfm?key=exon Exon. Diagram http://www.accessexcellence.org/AB/GG/exon.html Exon. is_part_of Chromosome. Fungus. graphic Fungus. is_type_of Biological_pathogen. Fungus. is_type_of Living_organism. Fungus. Predates Nematode. Fungus. Traps http://www.biological-research.com/philip-jacobs%20BRIC/fangorg.htm Gene. Drawing http://intron.bic.nus.edu.sg/exint/descrip.html Gene. Gene terms http://www.informatics.jax.org/searches/GO.cgi?id=GO:0030101 Gene. has_part Nucleotide. Gene. Regulation http://www.accessexcellence.org/AB/GG/combi_Control.html Gene. Tool Uni_gene. Genetics. graphic Genetics. has_type Genome. Genetics. has_type Organisation. Genetics. has_type Proteome Genome. description http://www.uq.edu.au/vdu/BasicsCell.htm Genome. has_part Chromosome. Genome. has_type Eukaryotic Genome. has_type Prokaryotic Genome. Human. http://www.ncbi.nlm.nih.gov/mapview/map_search.cgi?chr=hum_chr.inf&query GO_gene_ontology. Discussion ../content/gene_ontology. GO_gene_ontology. is_instance_of Organisation. GO_gene_ontology. Summary ../content/gene_ontology_go. GO_gene_ontology. Web_interface http://www.informatics.jax.org/searches/GO_form.shtml GO_gene_ontology. Web_interface, genes http://www.informatics.jax.org/searches/GO.cgi?id=GO:0030101 Haemophilia. ../concept/statistics. Statistics_about_Haemophilia Haemophilia. APTT Activated Partial Thromboplastin Time Haemophilia. Aquired_haemophilia Myocardial_infarction Haemophilia. association ../medicine/health_care. Haemophilia. Centres http://ukhcdo.org/HaemophiliaCentres/areacontactslist.htm Haemophilia. CJD, mad cow disease Patient_letter (PDF) Haemophilia. CJD_prions ../genetics/prion.htm Haemophilia. Data_collection Clinical_coding Haemophilia. Data_collection_Canada Canada Haemophilia. Data_management ../concept/data_management. Haemophilia. Definition http://www.healthline.com/galecontent/hemophilia-1 Haemophilia. Employment ../medicine/agenda_for_change. Haemophilia. Fragile_X_chromosome http://jmg.bmj.com/cgi/content/abstract/31/12/950 Haemophilia. Haemophilia_mild Produce 6% to 50%of the clotting factor Haemophilia. Haemophilia_moderate Only produce 2% to 5% of the clotting factor Haemophilia. Haemophilia_severe Only produce 1% of the clotting factor Haemophilia. Haemophilia_treatment Southampton Bookings Haemophilia. Haemophilia_types_source http://kidshealth.org/teen/diseases_conditions/blood/hemophilia.html Haemophilia. Haemotology Haemotology at Southampton Haemophilia. ICD_10_codes III D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Haemophilia. is_type_of ../medicine/medicine. Haemophilia. Manage_data ../concept/data_management. Haemophilia. Procedure Peripheral blood stem cell harvesting Haemophilia. Procedure Plasma exchange Haemophilia. Procedure Red cell exchange Haemophilia. Procedure Therapeutic leucapheresis Haemophilia. Procedure Therapeutic platelet apheresis Haemophilia. Risk Risk_assessment Haemophilia. Royal_family Haemophilia. Safe_sedation http://www.rcr.ac.uk/publications.aspx?PageID=310&PublicationID=186 Haemophilia. Society Haemophilia Society Haemophilia. Southampton Southampton University Hospitals Haemophilia. Southampton_patient_opinions Patient_feedback Haemophilia. Symptons Bleeding, Bruising easily, Clotting difficulty Haemophilia. Type_A 80% of cases, (lacking in factor VIII [8]) Haemophilia. Type_B 20% of cases, (lacking in factor IX [9]) Haemophilia. UKCDO, UK Haemophilia Centre Doctors Organisation http://ukhcdo.org/ Haemophilia. VisWiki http://viswiki.com/en/Haemophilia Haemophilia. What_causes_haemophilia? http://www.nhlbi.nih.gov/health/dci/Diseases/hemophilia/hemophilia_causes.html Human. graphic Intron. Discussion http://post.queensu.ca/~forsdyke/introns.htm#Introns%20Introduction Intron. is_part_of Chromosome. Intron. Purpose http://www.newton.dep.anl.gov/askasci/bio99/bio99375.htm Living_organism. has_type Animal. Meiosis. Explained http://www.accessexcellence.org/AB/GG/meiosis.html Meiosis. graphic, linked Mitosis. Animation http://www.cellsalive.com/mitosis.htm Nucleosome. description http://www.accessexcellence.org/RC/VL/GG/nucleosome.html Nucleosome. description http://www.average.org/~pruss/nucleosome.html Nucleosome. graphic Nucleosome. Incorporation into Chromatin http://www.albany.edu/~achm110/nucleosome.html Nucleotide. Diagram http://www.accessexcellence.org/AB/GG/nucleotide2.html Nucleotide. Explained http://life.fudan.edu.cn/inforservice/dictionary/Glossary/nucleoti.htm Nucleotide. is_part_of DNA. Nucleotide. is_part_of RNA. Nucleotide. Metabolism http://themedicalbiochemistrypage.org/ Organisation. EMBL_Bank http://www.ebi.ac.uk/embl/Access/index.html Organisation. has_instance GO_gene_ontology. Organisation. Sanger_institute. http://www.sanger.ac.uk/ Parasitism. definition Predation without killing host Prion. Definition Natural proteins that have changed in a harmful way, are hard to remove from the food chain and are infectious: Prion. description Prions are pathogenic variants of proteins that are naturally produced in nerve cells and certain other cells. The normal healthy prions are referred to as PrPc 0roteinaceous infectious particle and so should properly only be applied to the pathogenic variants. RNA that codes for PrPc is produced in the nucleus and exits via the nuclear pore. The RNA then passes along ribosomes attached to the rER. PrPc is formed in the rER and then progresses up through the Golgi. At the upper face of the Golgi, vesicles containing PrPc bud off and travel to the cell surface. Here, they fuse with the cell membrane and so discharge their cargo at PrPc. By this means, the cellular proteins come to sit on the exterior of the cell. PrPc encounter rogue (purple) prions. These are termed PrPsc (sc stands for scrapie, the prion disease of sheep). The rogue prions seem to force the normal proteins to change shape. Both types of protein, the PrPc and their corresponding prions, are the same chemical - just different shapes. It is this shape-flipping which is equivalent to the transmission of infection. Such a conformational shift or flip could happen at the cell surface or in caveolae (one is shown as a small invagination in the cell membrane). Residual PrPc might continue to be flipped by contact with the rogue confomations for some time in these vesicles. Prions polymerise, finally appearing as purple fibrils in the picture at P. PrPsc is resistant to degradation by the enzymes contained in the lysosomes that are seen floating nearby. Consequently, PrPsc accumulates in the cell. PrPsc vesicles may also travel to the Golgi and intercept PrPc that is being processed there. In this way, PrPc particles could be switched to the rogue form before they reach the surface of the cell. By such mechanisms, PrPc might be switched to PrPsc at various points in and on the cell. It must be emphasised that prion biology is not fully understood and much remains speculative Prion. graphic Prion. is_type_of Biological_pathogen. Prion. is_type_of Living_organism. Prion. Predates Human. Prion. Predation Parasitism. Protozoan. graphic Protozoan. is_type_of Biological_pathogen. Protozoan. Sporozoan http://orion1.paisley.ac.uk/courses/Tatner/biomedia/units/prot6.htm RNA. Diagram http://www.accessexcellence.org/AB/GG/rna.html RNA. has_part Nucleotide. RNA. has_type Rna_polymerase. RNA. Stands for Ribonucleic Acid Rna_polymerase. Diagram http://www.genome.jp/kegg/pathway/map/map03020.html Sanger_institute. Cancer Genome Project http://www.sanger.ac.uk/genetics/CGP/ Sanger_institute. is_type_of Organisation. Sympatric. description Live in same location Sympatric. Speciation http://evolution.berkeley.edu/evosite/evo101/VC1eSympatric.shtml Telomere. Ageing Theory http://www.aeiveos.com/agethry/telomere/ Telomere. Atlas http://genes.uchicago.edu/telomere/telomere.html Telomere. definition The end of a chromosome. This specialized structure is involved in the replication and stability of linear DNA molecules Telomere. graphic Transcription. Diagram http://www.accessexcellence.org/AB/GG/central.html Uni_gene. definition http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=unigene Virus. description Although they reproduce, they can only do so only by entering a host cell and making use of its machinery for replication. Viruses are bits of genetic material, apparentlyderived from their hosts. Thus, as Margulis and Schwartz (1988) put it, the polio and flu viruses are probably more closely related to people, and the tobacco mosaic virus (TMV) to tobacco, than polio and TMV are to each other Virus. graphic Virus. Image http://www.rkm.com.au/imagelibrary/index.html Virus. is_type_of Biological_pathogen. Virus. is_type_of Living_organism. Virus. Predates Human. Virus. Predation Parasitism. 153 total tuples     Vr.154, Jan 2009     Readme