Haemophilia. ../concept/statistics. Statistics_about_Haemophilia Telomere. Ageing Theory http://www.aeiveos.com/agethry/telomere/ Mitosis. Animation http://www.cellsalive.com/mitosis.htm Haemophilia. APTT Activated Partial Thromboplastin Time Haemophilia. Aquired_haemophilia Myocardial_infarction Haemophilia. association ../medicine/health_care. Chromosome. association Lariat Chromosome. association Snurp DNA. association Transcription. Telomere. Atlas http://genes.uchicago.edu/telomere/telomere.html Sanger_institute. Cancer Genome Project http://www.sanger.ac.uk/genetics/CGP/ Haemophilia. Centres http://ukhcdo.org/HaemophiliaCentres/areacontactslist.htm Haemophilia. CJD, mad cow disease Patient_letter (PDF) Haemophilia. CJD_prions ../genetics/prion.htm Haemophilia. Data_collection Clinical_coding Haemophilia. Data_collection_Canada Canada Haemophilia. Data_management ../concept/data_management. Exon. definition http://www.genome.gov/glossary.cfm?key=exon Haemophilia. Definition http://www.healthline.com/galecontent/hemophilia-1 Uni_gene. definition http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=unigene Prion. Definition Natural proteins that have changed in a harmful way, are hard to remove from the food chain and are infectious: Parasitism. definition Predation without killing host Telomere. definition The end of a chromosome. This specialized structure is involved in the replication and stability of linear DNA molecules Virus. description Although they reproduce, they can only do so only by entering a host cell and making use of its machinery for replication. Viruses are bits of genetic material, apparentlyderived from their hosts. Thus, as Margulis and Schwartz (1988) put it, the polio and flu viruses are probably more closely related to people, and the tobacco mosaic virus (TMV) to tobacco, than polio and TMV are to each other Nucleosome. description http://www.accessexcellence.org/RC/VL/GG/nucleosome.html Nucleosome. description http://www.average.org/~pruss/nucleosome.html Genome. description http://www.uq.edu.au/vdu/BasicsCell.htm Chromosome. description http://www.uq.edu.au/vdu/DNAGenes.htm Allopatric. description Live in different locations Sympatric. description Live in same location Prion. description Prions are pathogenic variants of proteins that are naturally produced in nerve cells and certain other cells. The normal healthy prions are referred to as PrPc 0roteinaceous infectious particle and so should properly only be applied to the pathogenic variants. RNA that codes for PrPc is produced in the nucleus and exits via the nuclear pore. The RNA then passes along ribosomes attached to the rER. PrPc is formed in the rER and then progresses up through the Golgi. At the upper face of the Golgi, vesicles containing PrPc bud off and travel to the cell surface. Here, they fuse with the cell membrane and so discharge their cargo at PrPc. By this means, the cellular proteins come to sit on the exterior of the cell. PrPc encounter rogue (purple) prions. These are termed PrPsc (sc stands for scrapie, the prion disease of sheep). The rogue prions seem to force the normal proteins to change shape. Both types of protein, the PrPc and their corresponding prions, are the same chemical - just different shapes. It is this shape-flipping which is equivalent to the transmission of infection. Such a conformational shift or flip could happen at the cell surface or in caveolae (one is shown as a small invagination in the cell membrane). Residual PrPc might continue to be flipped by contact with the rogue confomations for some time in these vesicles. Prions polymerise, finally appearing as purple fibrils in the picture at P. PrPsc is resistant to degradation by the enzymes contained in the lysosomes that are seen floating nearby. Consequently, PrPsc accumulates in the cell. PrPsc vesicles may also travel to the Golgi and intercept PrPc that is being processed there. In this way, PrPc particles could be switched to the rogue form before they reach the surface of the cell. By such mechanisms, PrPc might be switched to PrPsc at various points in and on the cell. It must be emphasised that prion biology is not fully understood and much remains speculative Transcription. Diagram http://www.accessexcellence.org/AB/GG/central.html DNA. Diagram http://www.accessexcellence.org/AB/GG/dna_molecule.html Exon. Diagram http://www.accessexcellence.org/AB/GG/exon.html Nucleotide. Diagram http://www.accessexcellence.org/AB/GG/nucleotide2.html RNA. Diagram http://www.accessexcellence.org/AB/GG/rna.html Rna_polymerase. Diagram http://www.genome.jp/kegg/pathway/map/map03020.html GO_gene_ontology. Discussion ../content/gene_ontology. Intron. Discussion http://post.queensu.ca/~forsdyke/introns.htm#Introns%20Introduction Gene. Drawing http://intron.bic.nus.edu.sg/exint/descrip.html Organisation. EMBL_Bank http://www.ebi.ac.uk/embl/Access/index.html Haemophilia. Employment ../medicine/agenda_for_change. Nucleotide. Explained http://life.fudan.edu.cn/inforservice/dictionary/Glossary/nucleoti.htm Meiosis. Explained http://www.accessexcellence.org/AB/GG/meiosis.html Chromosome. Fragile X chromosome http://jmg.bmj.com/cgi/content/abstract/31/12/950 Haemophilia. Fragile_X_chromosome http://jmg.bmj.com/cgi/content/abstract/31/12/950 Gene. Gene terms http://www.informatics.jax.org/searches/GO.cgi?id=GO:0030101 Animal. graphic Telomere. graphic Bacterium. graphic Fungus. graphic Genetics. graphic Human. graphic Protozoan. graphic Nucleosome. graphic Biological_pathogen. graphic Prion. graphic Virus. graphic Meiosis. graphic, linked Haemophilia. Haemophilia_mild Produce 6% to 50%of the clotting factor Haemophilia. Haemophilia_moderate Only produce 2% to 5% of the clotting factor Haemophilia. Haemophilia_severe Only produce 1% of the clotting factor Haemophilia. Haemophilia_treatment Southampton Bookings Haemophilia. Haemophilia_types_source http://kidshealth.org/teen/diseases_conditions/blood/hemophilia.html Haemophilia. Haemotology Haemotology at Southampton Organisation. has_instance GO_gene_ontology. Genome. has_part Chromosome. Chromosome. has_part Ciston (encodes a protein) Chromosome. has_part Exon. DNA. has_part Exon. Chromosome. has_part Gene. Chromosome. has_part Intron. DNA. has_part Intron. Gene. has_part Nucleotide. DNA. has_part Nucleotide. RNA. has_part Nucleotide. Chromosome. has_part Telomere. Living_organism. has_type Animal. Biological_pathogen. has_type Bacterium. Genome. has_type Eukaryotic Biological_pathogen. has_type Fungus. Genetics. has_type Genome. Biological_pathogen. has_type Invisible to naked eye Genetics. has_type Organisation. Biological_pathogen. has_type Prion. Genome. has_type Prokaryotic Genetics. has_type Proteome Biological_pathogen. has_type Protozoan. RNA. has_type Rna_polymerase. Biological_pathogen. has_type Virus. DNA. History http://library.thinkquest.org/20830/Textbook/HistoryofDNAResearch.htm Allopatric. How species originate http://en.wikipedia.org/wiki/Allopatric_speciation Genome. Human. http://www.ncbi.nlm.nih.gov/mapview/map_search.cgi?chr=hum_chr.inf&query Haemophilia. ICD_10_codes III D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Virus. Image http://www.rkm.com.au/imagelibrary/index.html Nucleosome. Incorporation into Chromatin http://www.albany.edu/~achm110/nucleosome.html GO_gene_ontology. is_instance_of Organisation. Exon. is_part_of Chromosome. Intron. is_part_of Chromosome. Nucleotide. is_part_of DNA. Chromosome. is_part_of Genome. Nucleotide. is_part_of RNA. Haemophilia. is_type_of ../medicine/medicine. Bacterium. is_type_of Animal. Fungus. is_type_of Biological_pathogen. Bacterium. is_type_of Biological_pathogen. Protozoan. is_type_of Biological_pathogen. Virus. is_type_of Biological_pathogen. Prion. is_type_of Biological_pathogen. Animal. is_type_of Living_organism. Biological_pathogen. is_type_of Living_organism. Fungus. is_type_of Living_organism. Virus. is_type_of Living_organism. Prion. is_type_of Living_organism. Sanger_institute. is_type_of Organisation. Haemophilia. Manage_data ../concept/data_management. Nucleotide. Metabolism http://themedicalbiochemistrypage.org/ Bacterium. Predates Human. Virus. Predates Human. Prion. Predates Human. Fungus. Predates Nematode. Bacterium. Predation Parasitism. Virus. Predation Parasitism. Prion. Predation Parasitism. Haemophilia. Procedure Peripheral blood stem cell harvesting Haemophilia. Procedure Plasma exchange Haemophilia. Procedure Red cell exchange Haemophilia. Procedure Therapeutic leucapheresis Haemophilia. Procedure Therapeutic platelet apheresis Intron. Purpose http://www.newton.dep.anl.gov/askasci/bio99/bio99375.htm Gene. Regulation http://www.accessexcellence.org/AB/GG/combi_Control.html Haemophilia. Risk Risk_assessment Haemophilia. Royal_family Haemophilia. Safe_sedation http://www.rcr.ac.uk/publications.aspx?PageID=310&PublicationID=186 Organisation. Sanger_institute. http://www.sanger.ac.uk/ Haemophilia. Society Haemophilia Society Haemophilia. Southampton Southampton University Hospitals Haemophilia. Southampton_patient_opinions Patient_feedback Sympatric. Speciation http://evolution.berkeley.edu/evosite/evo101/VC1eSympatric.shtml Protozoan. Sporozoan http://orion1.paisley.ac.uk/courses/Tatner/biomedia/units/prot6.htm DNA. Stands for Deoxyribo Nucleic Acid RNA. Stands for Ribonucleic Acid GO_gene_ontology. Summary ../content/gene_ontology_go. Haemophilia. Symptons Bleeding, Bruising easily, Clotting difficulty Gene. Tool Uni_gene. Fungus. Traps http://www.biological-research.com/philip-jacobs%20BRIC/fangorg.htm Haemophilia. Type_A 80% of cases, (lacking in factor VIII [8]) Haemophilia. Type_B 20% of cases, (lacking in factor IX [9]) Haemophilia. UKCDO, UK Haemophilia Centre Doctors Organisation http://ukhcdo.org/ Haemophilia. VisWiki http://viswiki.com/en/Haemophilia GO_gene_ontology. Web_interface http://www.informatics.jax.org/searches/GO_form.shtml GO_gene_ontology. Web_interface, genes http://www.informatics.jax.org/searches/GO.cgi?id=GO:0030101 Haemophilia. What_causes_haemophilia? http://www.nhlbi.nih.gov/health/dci/Diseases/hemophilia/hemophilia_causes.html 153 total tuples     Vr.154, Jan 2009     Readme