Review of the School of Biological Sciences, January 2004

 

Panel members

 

Professor M J P Arthur, Dean of the Faculty of Medicine, Health and Life Sciences (MHLS) [Chair]

Dr J A Allen, Director of Education, School of Biological Sciences (SBS)

Dr I G Giles, Associate Dean for Education, Faculty of MHLS

Professor P J Gregson, Deputy Vice-Chancellor

Professor P A Nelson, Director of Institute of Sound Vibration and Research

Professor V H Perry, Director of Research, SBS

Dr D Shepherd, Head of SBS

Mrs M A Smith, School Manager, SBS

Professor J E Stevenson, Associate Dean for Research, Faculty of MHLS

Mr R M Tank, Faculty Executive Officer, MHLS (Secretary)

 

1          Background

 

Following the 2003/04 strategic planning cycle, the University’s Senior Management Group (now the University Executive Group) asked the Dean of MHLS to undertake a full review of the SBS, with the primary aim of improving the School’s national and international standing in both research and education.  An important consideration would be to prepare the School for the next Research Assessment Exercise (RAE). 

 

The two main reasons for requesting a review were as follows:

·        The importance of biosciences to other parts of the University, both within the Faculty of MHLS and in the Faculty of Engineering, Science and Mathematics

·        Concerns about some of the School’s performance data, particularly relatively low “A” level entry scores and flat, or declining, research income in recent years

 

The review would consider all aspects of the School’s activities including: research activity, income and facilities; degree programmes; student numbers; teaching loads; administration, space and finances.

 

Full terms of reference for the review are included in Appendix A.

 

2          Review process

 

In preparation for the review, each of the School’s three Research Divisions held an awayday in December 2003 and reports of these meetings were made available to the panel.  Discussion at these awaydays was focussed on a series of questions prepared by the Head of School (see Appendix B). In addition, the Head of School produced a summary of the main issues facing SBS, with supporting management information. Other documents seen by the panel included:

·        Form RA5 from the 2001 RAE

·        Report of a meeting to review the interactions between the Division of Biochemistry and Molecular Biology (SBS) and Chemical Biology (School of Chemistry) [Appendix C]

·        A list of academic staff

 

The main part of the review took place over three days in early January 2004.  The leadership of each of the Research Divisions was asked to present a SWOT analysis, followed by discussion with the panel.  Other members of each Division then met the panel to explore the issues further.  Informal lunchtime meetings were held with the School’s technical, research and clerical staff.  Members of the panel also met a number of academic staff individually to discuss particular issues and matters of concern.

 

3          Achievements of SBS

 

The panel wished to place on record the achievements of the School, in particular the score of 23 in the QAA subject review and a grade 5 in the 2001 RAE.  The review process was designed to help the School build on its many strengths and ensure its successful future. The recommendations below should be seen in the context of significant changes that had already occurred within the School.

 

4          Current structure of the School (from August 2003)

 

The SBS was currently organised into three Research Divisions:

·        Biochemistry and Molecular Biology (BCMB)

·        Biodiversity and Ecology (BED)

·        Cell Sciences (Cell)

 

The three Heads of the Research Divisions were members of the School’s Policy and Resources Committee (PRC), which also included:

·        Head of School (Chair)

·        Director of Education

·        Director of Research

·        Two representative Degree Programme Managers

·        School Manager

·        School Accountant

 

Taught degree programmes were clustered into the following six groups, each with a Programme Manager who was a member of the School’s Academic Standards and Quality Committee (ASQC):

·        Biology

·        Biochemistry

·        Biomedical Sciences

·        Medical and Paramedical

·        Nutritional Science

·        Pharmacology

 

The other members of ASQC were as follows:

·        Director of Education (Chair)

·        Head of School

·        Head of Graduate School

·        Head of Recruitment

·        Associate Dean (Education)

·        Teaching Administrator

 

A diagram showing the whole structure is included as Appendix D.

 

5          Recommendations

 

5.1       Culture change

 

The panel believed that a change in culture was necessary for the School to fulfil its potential.  The main aspects of the new culture were as follows:

 

5.1.1    A more managed School

 

The panel recommended that:

·        The Head of School should be recognised to have the executive authority to act decisively where necessary.

·        There should also be:

Ø      a larger management team to support the Head of School – see 5.2.1 below;

Ø      more equitable and transparent workloads for all staff.

 

There was overwhelming support from members of the School for the principle of securing greater equity in workloads, though there were concerns about how such a system would operate in practice. The panel recommended that the Head of School put in place a matrix model of workload management, taking account of each academic’s teaching, research and administrative duties. The matrix would be reviewed and refined each year and form part of an active and ongoing management of workloads. The School of Psychology already had such a system in operation, which would be of interest to SBS. 

 

The panel recognised that the advantages of closer managerial involvement had to be explained to staff.  These included:

·        Greater understanding of the work of individual members of staff

·        The ability to offer support to colleagues where necessary

·        The chance to represent the concerns of a group to more senior colleagues

·        Better career development

·        More efficient use of resources (staff time, space and  equipment)

 

5.1.2        Management of space and cost savings on equipment

 

The School was currently devoting 19% of its total income (one third of its HEFCE income) to space charges – some £1.2m a year.  This figure was considerably higher than for most other Schools in the University.  Space was an important resource, which had to be balanced against other demands on the budget, notably staff costs. 

 

The panel recommended that the School undertake a major space review to determine precisely who was responsible for each part of the building and what charges were attached to that space.  The School should then establish a committee, chaired by the Head of School, to monitor and review the use of space.  The School might also wish to devolve space budgets to Research Groups (see 5.2 below), though the administrative costs associated with such a move had to be taken into account.

 

The School was currently spending about £500k a year of HEFCE income on equipment.  The panel recommended that, wherever possible, research equipment, maintenance and replacement costs should be funded from research grants and not HEFCE income, as was common practice elsewhere in the University.  This would free up HEFCE recurrent income to invest in the future strategic direction of the School.

 

5.1.3    A more outward-looking attitude

 

The panel recommended that there should be more engagement between the School’s academic staff and external organisations (e.g. Research Councils; charities and other funding bodies; key national and international committees).  The School should aim not simply to respond to the external agenda, but to influence the debates.

 

5.2       Integration of research activities

 

The panel recommended that the School be re-structured into the following Research Groups:

·        Developmental and Cell Biology

·        Ecology

·        Microbiology (an area for possible future growth, in collaboration with the School of Medicine and the School of Ocean and Earth Science)

·        Neurosciences

·        Plant Sciences

·        Structural Biology (in its widest context)

 

Each academic would have a primary affiliation to one Group, but this did not preclude collaboration with colleagues in other Groups where appropriate.

 

The aim of the re-structuring was to encourage greater flexibility and inter-disciplinary research – in the School, across the Faculty of MHLS and with research groups elsewhere in the University.  It would signal a departure from research organised according to specific disciplines, techniques or technologies, with the prime emphasis placed instead on solving scientific problems. It was expected that greater emphasis on inter-disciplinary research would lead to more successful research grant applications and thus create a virtuous cycle by securing increased funding.

 

The second advantage of smaller Groups was that they would be more manageable, in line with the recommendations in section 5.1.1 above.

 

5.2.1    Process for change

 

The School Management Committee would match all academic staff to a Research Group, on the recommendation of the Head of School.  Staff who had concerns about their allocation to a particular Group would have the opportunity to discuss the matter with the Head of School.  However, final decisions about where staff would sit in the new structure would rest with the Head of School.

 

Each Research Group would be managed by a senior member of staff, appointed by the Head of School, following a process of consultation.  A clearly defined job description for the role should be developed. Chairs of Research Groups would receive the necessary training and support for their roles and would be appointed for a limited period, with the possibility of one renewal. 

 

The Chairs of Research Groups, with the Head of School and Director of Research, would form a new Research Committee, with responsibility for the following:

·        Formulating the School’s research strategy

·        Interactions with other Schools within the University, to promote major research initiatives (e.g. the Life Science Interface)

·        Taking a view of research funding from outside bodies, including Research Councils, the UK government, the EU and major charities

·        Having oversight of School-wide research facilities

 

The panel recommended that, as part of the re-structuring process, technical and clerical support for academic staff should be reviewed. In particular, it was felt that line management issues among technical staff must be addressed, to ensure equitable workloads and to create better career development opportunities.

 

5.2.2    Other ways of encouraging integration

 

The panel identified a number of other ways in which greater integration of staff across the School could be encouraged.  These included:

·        The creation of a coffee room

·        A series of School-wide seminars

·        School Awaydays, at least once a year

·        Greater integration of post-doctoral research staff

·        School-wide, cross-Group, research studentships

 

5.3       Educational provision

 

5.3.1    Establishment of a separate Education Group

 

The panel debated the pros and cons of establishing a separate Education Group, alongside the Research Groups.  This worked well in the School of Medicine and elsewhere in the Faculty of MHLS. Advantages included:

·        Raising the profile of education and helping to ensure parity of esteem with research

·        Giving interested staff the opportunity to specialise in educational issues and to become expert in current debates about quality assurance and enhancement

·        The creation of alternative career paths for staff whose prime interest was in education rather than research 

 

Disadvantages included:

·        The danger of “education-led” staff losing touch with research and thus becoming disengaged from other key activities in the School

·        The possibility that the Education Group would lack the focus and common purpose of the Research Groups

 

The panel concluded that, on balance, it would not be advantageous to form a separate Education Group at this time.  Staff who were not research-active would join one of the Research Groups listed above and could take particular responsibility for educational initiatives within the School. Where possible, such staff would be supported to develop or enhance their research profile for the next RAE

 

5.3.2    Undergraduate curriculum

 

The panel recommended that the School undertake a fundamental review of its undergraduate curricula, with the aim of making the degree programmes more modern and distinctive, with a more streamlined programme delivery.  It was expected that such a review would lead to a reduction in the total number of degree programmes – a process that the School had already begun.

 

The review should take account of the University’s commitment to student-centred, research-led education.  The following questions should therefore inform the debate:

·        What were the future growth areas for undergraduate education in the biological sciences?

·        What were the expected impacts of developments within the 11-18 curriculum?

·        How did the undergraduate curricula reflect and build on the principal research interests of the School?

·        If an undergraduate programme did not reflect such an interest, what justification was there for continuing to teach it? (Cf. University’s corporate strategy)

·        What would be distinctive about the biological science degree portfolio at Southampton?

·        How would the introduction of variable tuition fees (assuming this happened) affect student expectations of a University education?  How would the School position itself to meet these expectations?

·        How well did the undergraduate curricula prepare students for employment afterwards?   How marketable would SBS graduates be?

 

The review should also embrace:

·        The future of the Nutritional Sciences degree (in consultation with the School of Medicine)

·        Mechanisms for student support across the School, with the aim of unifying practice for pastoral support and tutorials, and ensuring a common regulatory framework for all undergraduate degree programmes.

 

The Director of Education would lead the process of review, in consultation with the Programme Directors and other colleagues within the School. 

 

A curriculum plan should be produced by May 2004 and the School should work towards implementing the new curricula by the start of the 2005/06 session.

 

5.3.3    Postgraduate programmes

 

As longer-term objectives, the panel recommended that the School should:

·        Aim to attract greater numbers of well-qualified postgraduate research students and ensure that they were integrated into a vibrant postgraduate community

·        Consider the creation of a larger number of Masters level programmes

·        Aim to recruit more international PGR and PGT students

 

5.3.4    Service teaching

 

The panel recommended that service teaching for other Schools should only be undertaken when there was a sound academic reason for doing so.  Agreements should be reached through bilateral discussions with other Schools concerned, as part of a managed process and subject to the agreement of the Head of School.  If it was not possible to reach agreement with another School, the matter should be referred to the Faculty Strategy and Policy Group for resolution.

 

6          Timetable and next steps

 

The panel recommended that the School should move as rapidly as possible to implement the proposals in this report.  Key milestones included:

·        Immediate allocation of staff to Research Groups (January 2004)

·        The appointment of Chairs of Research Groups and the establishment of a Research Committee (January 2004)

·        The creation of a new curriculum map (May 2004)

 

The School should also produce a detailed action plan with other target dates. Advice should be sought immediately from the Human Resources Department about contractual issues affecting staff, periods of consultation, and due process.

 

The panel also recommended that the School establish an Advisory Group, with representatives from employers and other universities, to review the full range of education, research and enterprise activities within the School. The Group would meet once or twice a year, once the new structure was in place. 

 

The panel further recommended that the School review the new structure after two years of operation.

 

 

 

 

Appendix A: Terms of reference of the review

 

 

·        In response to the outcome of the 2003/2004 strategic planning cycle, SMG (now UEG) requested that the Dean of MHLS undertakes a full review of the School of Biological Sciences with the primary aim of improving the school’s national and international standing in both research and education. An important consideration will be to prepare the School for the upcoming RAE.

 

·        The Review will conducted by a Panel comprising the Dean of MHLS, Head of School, Director of Research, Director of Education, School Manager, the Associate Deans (MHLS) for Education and Research, Head of School from another Faculty (Prof. Phil Nelson, ISVR) and a DVC  (Prof. Peter Gregson). The Panel will be chaired by the Dean of MHLS and supported by the Faculty Executive Officer.

 

·        The Review will consider all aspects of the School’s activities including: research activity, research income, research facilities, degree programmes, student numbers, teaching loads, administration, space and finances. The review will take place during this session and will provide a written report for UEG by February/March 2004.

 

The aims of the Review are to:

 

·        Define a clear focus for the School's activities, to identify areas and approaches that have been successful upon which to build and to identify failings and recommend a clear strategy to remedy them. This will ensure that the strengths and successes of the school are identified to provide the focus necessary to:

                                                                                                                                                                          

a)      Improve the School’s research performance and raise both its profile and rating.

 

b)      Develop the School’s profile in education, and raise its rating.

 

·        Consider the School’s Divisional and/or management structures and, if necessary, to reconfigure them to achieve the focus and synergies required for improved performance in research and education

 

·        Consider the Schools degree programmes to ensure that they are appropriately matched to delivering research-led, student-centred, education.  Proposals to alter programmes or to start new ones will be considered in the light of an analysis of the market for such programmes and of the costs involved in delivery.

 

·        To develop and advise on implementation (through the annual appraisal process) of agreed workload and performance criteria for all categories and grades of staff.

 

·        To assess and improve the local implementation of the annual appraisal process so that it becomes the cornerstone of an equitable, effective and user-friendly process for individual career development.

 

Conduct of the Review

 

·        The Review will be evidence based. A detailed analysis of management information relevant to the School’s activities will be conducted. The management information will include: research applications and awards, publication profile (best 4 publications from each member of staff since Jan 1st 2001), central research facilities, application and admission statistics, teaching loads, class sizes, administration loads, number and deployment of technical and clerical staff, and space usage. Where possible, the Review will be benchmarked by comparison with datasets from other Schools and HEIs.

 

·        Data will be analysed by Division, Research Group and individual to provide a detailed image of research and teaching performance and to identify the areas of success and weakness within the school. This analysis will also identify where a balance or imbalance exists between teaching and research.

 

·        The Review will use the benchmarked information in conjunction with the Career Pathway and Job family process to establish expected workload and performance norms for all grades and categories of staff in the School. Specifically, this will involve contextualisation of the Job Family Career Pathways Booklet for the School. This will set the expected workload and performance standards for all categories of staff in the School and provide the independent metrics needed for the fair and objective assessment of individual staff performance.

 

·        The Review will audit central research facilities for annual turnover and usage as a prerequisite for a more managed approach to running and developing the research infrastructure. This will seek to optimise ease of use and to maximize their research effectiveness.

 

·        Each Head of Division will receive a performance analysis and relevant management information for their Division from the Review Panel. To ensure full involvement of staff, Heads of Division will meet with their staff to discuss the performance analysis and to prepare a response. The Divisions will be asked to respond to questions arising from the Review Panel’s analysis, to perform SWOT or similar analyses and to present their view of the best strategy for their future.

 

·        The Review Panel will hold a one-day meeting with each Division. Each meeting will also consider relevant cross-cutting issues that affect the entire School. The meeting will involve the Review Panel with appropriate involvement of any research groups and educational programs that are relevant to the Division.  The aim will be to explore the results of the performance data and to discuss and develop strategic plans and conclusions.

 

·        The Review Panel may wish to call further meetings to address cross-cutting School wide issues in further detail. The need for such meetings and their content will be formulated during the review process.

 

·        The conclusions of the Review Panel will be formulated into a single report for the School. The report will summarise the results of the analysis and provide clear recommendations.  Each Division will be asked to consult with all staff and to comment on the report.

 

·        At the end of the Review and after consideration of the responses of each Division to the initial conclusions and recommendations, the Review Panel will provide a final report to UEG. This final report will be circulated to all members of the School. 

 

·        This report will provide the framework of the strategic plan for 2004/2005. The report will also include a recommended set of workload and performance criteria for all categories and grades of staff.

 

Joint developments with Chemistry

 

In the case of the Division of Biochemistry and Molecular Biology there will be a review of the specific interactions between it and Chemical Biology (School of Chemistry). The aim is to establish if there are areas of common interest and to explore ways of developing and sustaining a world class biochemistry/chemical biology activity at Southampton.  The first phase of this aspect of the review has recently been completed and the Dean of MHLS is preparing a report that will be made available to the review panel once it has been seen and agreed by the participants from the Division of Biochemistry and Molecular Biology, Chemical Biology, both Heads of School and the Deans of ESM and MHLS.

 

 

Appendix B: Questions prepared by Head of School for Awaydays in December 2003


 

Education

 

·        What is distinctive about the School’s undergraduate programmes?

·        Do the current programmes on offer adequately reflect the School’s research focus and staff capabilities?

·        If not, what programmes could the School consider offering to provide a better match?

·        Do the current units on offer adequately reflect the School’s research focus and staff capabilities?

·        If not, what units could the School consider offering to provide a better match?

·        Do you have a view on the proportion of the School’s activities that should be directed towards service teaching?

·        Are all of the School’s current teaching activities sustainable?

·        If not, what changes are required to ensure sustainability?

·        Is there scope for cross-School degrees (e.g. with ECS or SOC)?

·        Is there scope for an increased provision of Masters programmes?

·        If so, in what areas could Masters be established?

·        How can the School improve the overall quality of its A-level intake?

·        How can the School increase international PG and UG student numbers?

·        How does the School ensure adequate resource allocation for education?

·        How does the School ensure equitable use of support staff?

·        How could the School improve the opportunities for staff to develop their skills in education?

 

The changing context

 

·        How effective is the personal tutorial system for providing the support that students expect?

·        What do you think is meant by student-centred education?

·        What will be the effect on the School of having to provide a more student-centred education?

·        What is the student entitlement model that the University has committed itself to?

·        What will be the impact on the School?

·        What effect will top-up fees have on the expectations of students?

·        How will the School’s education programmes adapt?

 

Research

 

·        What are the School’s research strengths?

·        What is distinctive about the School’s research strengths?

·        What factors hinder you from doing the research you want to do?

·        What measures could the School put in place to increase research income?

·        What measures could the School put in place to increase research productivity?

·        How difficult/easy is it for us to raise our national position?

·        What likely future developments is the School well placed to exploit?

·        What likely future developments is the School not well placed to exploit?

·        Are the current research facilities required and sustainable?

·        How can the organisation and management of central research facilities be improved to increase their use and productivity?

·        How could the School improve the opportunities for staff to develop their skills in research?

·        What are the priorities for investment/expansion in research?

·        How can we increase international PGR numbers?

·        Is PGR training a priority for the School?

·        Should a student-centred approach apply to PGR students?

·        What functions of a Faculty or University wide Graduate School would aid the School in the training of its PGR students?

 

Organisational issues

 

·        Is the current Divisional structure the best way to organise the School’s research?

·        What other groupings could be considered?

 

Enterprise and innovation

 

·        How should the School contribute to the University’s enterprise and innovation aspirations?

·        What new income streams could the School develop?

 

Workload issues

 

·        What is an acceptable workload for a student?

·        What is an acceptable teaching load for staff?

·        Is the current teaching load distribution fair for all staff?

·        If not, what measures should the School put in place to redress the balance?

·        How can research activity be factored into workload distribution?

 

 

Appendix C: A review of the interactions between the Division of Biochemistry and Molecular Biology (SoBS) and Chemical Biology (School of Chemistry)

 

Report of a meeting at Chilworth

 

This meeting was organised as the first stage of a review of the interactions between the Division of Biochemistry and Molecular Biology (BMB) in SoBS and Chemical Biology (ChemBio) in the School of Chemistry.  The meeting was organised at the request of the Vice Chancellor and the University Executive Group (UEG) following the annual strategic planning round (2003-2004).

 

The specific aims of the meeting were:

 

1.      To establish if there were areas of common intellectual interest between BMB and ChemBio and, if so, to explore ways of establishing a joint strategy that could be beneficial to both Schools.

 

2.      To establish whether there were possibilities for increased research collaboration between BMB and ChemBio, with respect to either research programmes and projects, or applications for (and the use of) advanced research equipment.

 

3.      To ensure that SBS and ChemBio were not inadvertently competing for the same pools of research money, e.g. at BBSRC and that bids from the University of Southampton to major funding initiatives appeared coordinated in this field of research.

 

 

Attendees

 

Present at the half day meeting were:

 

Professor MJP Arthur, Dean of MHLS (Chairman)

Professor JK Hammond, Dean of ESM

Dr David Shepherd, Head of the School of Biological Sciences

Professor J Kilburn, Head of the School of Chemistry

Professor K Fox, BMB

Professor M Gore, BMB

Professor G Attard, ChemBio

Professor M Bradley, ChemBio

 

 

Methodology

 

Following a brief introduction to discuss the scope and purpose of the meeting from Professor Arthur, presentations were given by the attending members of BMB and ChemBio that outlined their key areas of research interest and current research interactions between BMB and ChemBio.  These are summarized below.  A far ranging discussion followed which focussed on the specific aims of the meeting. The attendees at the meeting then agreed their conclusions and recommendations.

 

Summary of the research activity of BMB (SoBS)

 

Research in BMB is organised into two interactive areas of Structural Biochemistry and Molecular and Cellular Biochemistry.  

 

Structural Biochemistry includes three distinctive areas of research that focus on

·        Membranes and Proteins (Wilton, Lee, East and Anthony)

·        Molecular Recognition (Shoolingin-Jordan, Gore, Fox)

·        Structural Biology - NMR and Crystallography (Wood, J Cooper, A  Cooper, Werner, Findlow)

 

There are a wide ranging set of research interests within these groups that include studies of:

1.      Proteins at the phospholipid interface (human secreted PLA2)

2.      Membrane - protein interactions, Calcium pump

3.      Structure and Function of proteins in bacterial electron transport systems

4.      Aspartic proteases, enzymes of haem biosynthesis, polyketide synthesis

5.      Phosphorylation events in T cell activation, structure and function of immunoglobulin- binding proteins

6.      DNA recognition

7.      Pentraxins

8.      Solution NMR of protein-protein interactions in signalling complexes

 

This list is not exhaustive, but is outlined to provide an overview of the breadth of interests that are bound by a common interest in structure-function relationships of specific proteins or lipids across a broad range of biological systems. As a generalisation, the group tends to focus on individual specific proteins and their interacting partner molecules and for their studies there is a requirement to synthesize and purify large quantities of these proteins for analysis.

 

Molecular and Cellular Biochemistry includes two distinctive areas of research that focus on

·        Bacteriology (Keevil, O’Connor, Skipp)

·        Eukaryotic Signalling (Lillycrop, Sale, Barton)

 

Again there a wide ranging set of research interests that include studies of

1.      Environmental healthcare, including the bacteriology of food safety

2.      Molecular aspects of bacterial survival responses, host-microbe interactions and virulence

3.      Proteomics: application and development of novel approaches

4.      Transcription factors in neural development

5.      Natural resistance protein (NRamp-1) and macrophage ion transport

 

This broad range of research interests could be described as being more oriented on the application of biochemistry towards the study of important biological processes in eukaryotic and prokaryotic organisms.

 

Summary of the research activity of ChemBio

 

The current strategic plan for ChemBio is to focus on three key areas

·        Development of high throughput methodologies & their application in the life sciences

1.      Next generation of selectively tagged biomolecues

2.      Combinatorial mutagenesis technologies

3.      Genetic analysis for medical, crime prevention & anti-terrorism applications

4.      Array-based assays and Data Fusion

 

·        Expansion of theoretical chemical biology capabilities

1.      Modelling complex reaction networks

2.      Systems-oriented approach to biological problems

 

·        Strengthening of bioanalytical chemical biology

1.      High throughput Mass Spectrometry

2.      Mass Spectrometry applied to metabolomics

 

This strategy will be overlaid on current areas of research interest which include

 

·        Nucleic Acids

1.      Synthesis of chemically modified nucleic acids (Brown)

2.      Synthesis of antisense oligonucleotides (Brown)

3.      DNA triplexes for medicinal applications (Brown)

4.      DNA-protein interactions (Neylon)

5.      DNA-lipid-protein complexes (Attard)

 

·        Proteins and Enzymes

1.      The chemistry of unusual enzymes e.g. lipoic acid synthase (Neylon)

2.      Fluorescent labelling of proteins by intein-mediate ligation (Neylon)

3.      Expression plasmids for target-intein fusion proteins (Roach)

4.      Expression & characterisation of membrane receptors (Roach)

5.      Electron transfer in proteins studied by FRET & electrochemistry (Neylon)

6.      Modulation of enzyme activity by membrane lipid composition (Attard)

7.      Protein unfolding at membranes (Attard)

 

·        Applications of NMR & Mass Spectrometry to Structural Biology

1.      Application of mass spectrometry techniques to biology (Langley)

2.      Theory & methodological developments of solid-state NMR (Levitt)

3.      Picometre-scale structural biology of rhodopsin (Levitt)

4.      Solution NMR studies of heme-containing proteins (Turner)

5.      Theory & methodological developments of solution NMR (Turner)

 

·        Application of Modelling to Biological Problems

1.      Computer modelling of protein conformational changes (Essex)

2.      Membrane simulations & drug transport (Essex)

3.      Modelling of drug binding to receptors (Essex)

4.      Kinetic simulations of biochemical reaction networks (Attard)

5.      Mathematical modelling of immune responses (Attard)

 

·        High-throughput Chemical Biology

1.      Combinatorial Centre of Excellence (Bradley)

Libraries of bioactives

Cell permeable peptoids

PNA Encoding & DNA arrays

Transfection chips

Microarrays & printed slides

Cell Delivery

2.      Combinatorial biology/mutagenesis  (Neylon)

3.      4 billion bases a day - practical individual genome sequencing (Bradley)

 

This brief summary indicates that much of the research in ChemBio differs considerably from that currently being undertaken in BMB. In particular, the strategic emphases in ChemBio on (i) high throughput combinatorial methodologies,  (ii) bioanalytical chemistry and the application of novel chemical methodologies to facilitate the study of biochemical reactions and on (iii) theoretical chemical biology with modelling of complex networks of reactions are unique to ChemBio with no apparent overlap with BMB. 

 

Areas of research activity where there is active collaboration and other areas of apparent overlap are explored further in the next section.

 

 

Summary of areas of active collaboration and other apparent areas of overlap between BMB and ChemBio

 

Active collaborations

One area in which there is a very active and successful collaboration between BMB and ChemBio is in studies of DNA, between Prof. Tom Brown and Prof. Keith Fox. This research focuses on DNA recognition by triple helix formation, Protein DNA conjugates and DNA mismatch recognition. ChemBio provides expertise in synthetic chemistry and specialist DNA synthesis whereas BMB provides expertise in biophysical and biochemical studies of DNA. This collaboration has obtained the following grants since 1997: BBSRC (3), CRUK (2), AICR, EU Total: £1,17M

Current active grants include EU, BBSRC, and CRUK which funds 6 post-docs and 2 PhD students.

 

Other areas of apparent overlap

 

1.      NMR – Both BMB and ChemBio use NMR as a key methodology in their analysis of chemical and biochemical structures. There are NMR machines with different capability (Boldrewood has a 600Mhz liquid phase machine, Chemistry possesses a range of medium field, 300-400 MHz, NMR machines. These are used for solution experiments on small molecules (typically for structure determination and characterisation) and for solid-state experiments with resin-bound small molecules (produced in combichem projects). In addition there are two solid state NMR machines (300 MHz and 400 MHz) used by Prof Malcolm Levitt for his work on solid-state biological NMR. In BMB, NMR studies have focussed on solving structures of specific proteins and their interacting partners (other proteins or lipids) of interest in biological systems.  In contrast, ChemBio have been more focussed on studying the frontiers of NMR methodology and developing advanced NMR techniques, such as solid state NMR.  There are currently no active collaborations between both NMR groups. The recent appointment of Dr Jorn Werner in BMB has led to increased interaction between both groups and the prospect of new areas of collaborative research.  Prof Malcolm Levitt (solid-state biological NMR) and Jorn Werner/Tony Lee are currently putting together a proposal for an Advanced NMR laboratory combining expertises in solid-state and solution biological NMR. This could potentially provide a world-leading activity in this area.

 

 

2.      Lipids and Membrane-associated proteins – There is an apparent overlap in this area, but within BMB interests are oriented towards the study of a limited number of specific membrane associated proteins and their interactions with lipids in the cell membrane (e.g. phospholipase A2, calcium pump). In contrast, interests in Chembiol are more focussed on functional lipidomics and in modelling lipid network dynamics through the development of mathematical models of membrane phospholipid composition, synthesis and turnover.  It is envisaged that research in functional lipidomics will be a developing focus of the University initiative in the Life Sciences Interface.

 

Conclusions

 

Following lengthy and detailed discussion the following conclusions were reached:

 

1.      There was no evidence of overt competition between BMB and ChemBio for the same pots of research funding at BBSRC or other funding organisations. The research profiles of BMB and ChemBio are sufficiently different that this is not a practical problem.

 

2.      There was no prima facie case for a merger of BMB and ChemBio into a single entity (in either SoBS or Chemistry). Although such a merger would be theoretically possible, neither BMB nor ChemBio felt positive about such a suggestion. The main reason for this was the observed difference in research strategies and interests and the perception that there was no intellectual advantage to such a merger.  In the absence of a bilateral bottom-up academically driven wish to move in this direction, this option was not considered further. 

 

3.      Movements of smaller groups of staff or individuals was not considered during the meeting, but this would be possible if there was a specific desire from the academic(s) concerned, a sound intellectual basis and both Heads of School were in agreement.

 

4.      There is one successful collaboration between BMB and ChemBio, but no evidence of widespread collaborative research activity. In fact there are probably more collaborative projects between BMB and other parts of the University, e.g. SOC/SOES, Medicine than there are with ChemBio. Similarly, ChemBio probably has more collaborative activity with Medicine and elsewhere in ESM than with BMB.  These are factual observations, not criticisms.

 

5.      There is overlap in the application of structural biology methodologies such as NMR, with equipment provided at both sites. There are different applications for such equipment in BMB and ChemBio.

 

Recommendations

 

1.      BMB and ChemBio should not be merged, but should continue as integral parts of their parent schools for the foreseeable future.

 

2.      The interface between BMB and ChemBio should be actively managed by the Heads of both Schools in consultation with the Deans of MHLS and ESM. This should include an annual review of strategic direction and cross representation on strategic discussions about new appointments in both BMB and ChemBio.  Annual submissions to the strategic planning round should be shared between both schools.  Through this process, it is envisaged that a joint strategy that could be beneficial to both schools may emerge over time.

 

3.      The Heads of School and the Deputy Heads of School (Research) should continue to actively promote increased collaborative research between BMB and ChemBio.  Potential areas of interaction in the near future include Lipid Biochemistry and Functional Lipidomics or the application of NMR for structural biochemistry studies.

 

4.      The Heads of School and the Deputy Heads of School (Research) should plan collaboratively for major equipment bids, e.g. SRIF or external bidding rounds.  The University need to be constantly re-assured that there is no unnecessary reduplication of major equipment.

 

5.      The future strategic direction of BMB should now be considered within the context of the overall review of the School of Biological Sciences.  It will be important for that review to know that options for major interaction/merger with ChemBio are not considered to be a workable option for BMB

 

 

 

 

Appendix D: Current structure of the School

Text Box: Education and Quality Management

 

 

 

 

21 January 2004

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